Prevention of supersensitivity in partially isolated cerebral cortex.

Partial or total neuronal isolation of the cerebral cortex leads to changes in electrical afterdischarges, locally elicited by drug and electrical stimulation (Sharpless and Halpern 1962; Echlin and Battista 1963). Thresholds decrease and duration of after-discharges increases over weeks and months following partial or complete isolation of cerebral cortex. This phenomenon has been called supersensitivity. In the present series of experiments we have successfully altered the expected course of development of this type of supersensitivity.